Molluscicide nomenclature

Common name niclosamide (BSI, E-ISO, (m) F-ISO, BAN, Germany (for veterinary use))
IUPAC name 2, 5-dichloro-4 -nitrosalicylanilide
Chemical Abstracts name 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

CAS RN [50-65-7]

PHYSICAL CHEMISTRY

Mol. wt. 327.1
Form Almost colorless crystals.
M.p. 230 C
V.p. <1 mPa (20 C)
KOW logP = 1 (pH 9.6)

Solubility In water 1.6 (pH 6.4), 110 (pH 9.1) (both in mg/l, 20C). Soluble in common organic solvents such as ethanol and diethyl ether.

Stability Hydrolyzed in aqueous solution, DT50 (20C) c. 7 d (pH 6.9), 18.8 d (pH 13.3). Stable to heat. Decomposes under u.v. irradiation. Hydrolyzed by concentrated acid or alkali.

APPLICATIONS

Mode of action Molluscicide with respiratory and stomach action.

Uses Control of golden apple snail in rice. Control of schistosomiasis and fascioliasis in man by killing fresh-water snails which act as intermediate hosts. Also used for veterinary control of tapeworm infestations.

Compatibility Incompatible with acidic materials.
Selected tradename Bayluscide (EC250).