Baljit Nagar , New Delhi
Last Updated: 19 Jul, 2013

Piosys Tablet

Piosys Tablet
piosys belongs to the class of anti-diabetic drugs called "thiazolidinediones" that are used for the management of type ii diabetes mellitus.
mechanism of action piosys decreases insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Unlike sulfonylureas, pioglitazone is not an insulin secretagogue.

pioglitazone is a potent agonist for peroxisome proliferator-activated receptor-gamma (pparγ). Ppar receptors are found in tissues important for insulin action such as adipose tissue, skeletal muscle, and liver.

activation of pparγ nuclear receptors modulates the transcription of a number of insulin responsive genes involved in the control of glucose and lipid metabolism.
indication in type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus, niddm)
dosage piosys monotherapy is given in patients not adequately controlled with diet and exercise may be initiated at 15 mg or 30 mg once daily. For patients who respond inadequately to the initial dose of piosys, the dose can be increased in increments up to 45 mg once daily.
side effects edema , weight gain , anemia (1%) , myalgia (3%) , headache, hepatotoxicity (rare), fracture of bone,  macular retinal edema
  • heart failure may develop or be exacerbated due to fluid retention
  • edema; may initiate or worsen edema
  • active liver disease
  • diabetes mellitus, type 1; pioglitazone should not be used without insulin       
  • diabetic ketoacidosis; pioglitazone should not be used without insulin
  • contraindications
  • heart failure, new york heart association class iii or iv
  • hypersensitivity to pioglitazone
  • sales pack piosys : pack of 100 tabs/ box (10 x 10)

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